Toxicology Research,01 July 2016, Issue 4, Page 977 to 1258
链接：http://pubs.rsc.org/en/journals/journalissues/tx#!issueid=tx005004

CONTENTS
Review Article (综述)
1.Molecular and pathophysiological aspects of metal ion uptake by the zinc transporter ZIP8 (SLC39A8)
锌转运蛋白ZIP8(SLC39A8)对金属离子摄取的分子和病理生理机制
Zhong-Sheng Zang, Yan-Ming Xu and Andy T. Y. Lau
Toxicol. Res., 2016, 5, 987-1002 DOI: 10.1039/C5TX00424A

2.Biological effects, translocation, and metabolism of quantum dots in the nematode Caenorhabditis elegans
量子点在秀丽隐杆线虫体内的生物学效应、迁移和代谢
Dayong Wang
Toxicol. Res., 2016, 5, 1003-1011 DOI: 10.1039/C6TX00056H

Communications (交流)
1.A 7-methoxytacrine–4-pyridinealdoxime hybrid as a novel prophylactic agent with reactivation properties in organophosphate intoxication
7-甲氧基他克林-4-吡啶酮肟杂化物是一种新型的预防有机磷酸酯中毒的药物
E. Nepovimova, J. Korabecny, R. Dolezal, T. D. Nguyen, D. Jun, O. Soukup, M. Pasdiorova, P. Jost, L. Muckova, D. Malinak, L. Gorecki, K. Musilek and Kamil Kuca
Toxicol. Res., 2016, 5, 1012-1016 DOI: 10.1039/C6TX00130K

2.Cytotoxicity investigation of luminescent nanohybrids based on chitosan and carboxymethyl chitosan conjugated with Bi2S3 quantum dots for biomedical applications
壳聚糖和羧甲基壳聚糖修饰的Bi2S3量子点发光纳米杂化物的细胞毒性研究和生物医学应用
Sandhra M. Carvalho, Herman S. Mansur, Fábio P. Ramanery, Alexandra A. P. Mansur, Zelia I. P. Lobato and Maria F. Leite
Toxicol. Res., 2016, 5, 1017-1028 DOI: 10.1039/C6TX00039H


Papers (论著)
1.QSAR modeling for predicting reproductive toxicity of chemicals in rats for regulatory purposes
QSAR模型应用于化学物对大鼠生殖毒性预测和管理
Nikita Basant, Shikha Gupta and Kunwar P. Singh
Toxicol. Res., 2016, 5, 1029-1038 DOI: 10.1039/C6TX00083E

2. Multi-tissue metabolic responses of goldfish (Carassius auratus) exposed to glyphosate-based herbicide
草甘膦类除草剂诱导金鱼（鲫鱼）的多器官代谢应答
Ming-Hui Li, Hua-Dong Xu, Yan Liu, Ting Chen, Lei Jiang, Yong-Hong Fu and Jun-Song Wang
Toxicol. Res., 2016, 5, 1039-1052 DOI: 10.1039/C6TX00011H

3.Characterization of a functional C3A liver spheroid model
功能性C3A肝细胞球体模型的特征
Harriet Gaskell, Parveen Sharma, Helen E. Colley, Craig Murdoch, Dominic P. Williams and Steven D. Webb
Toxicol. Res., 2016, 5, 1053-1065 DOI: 10.1039/C6TX00101G

4. UVB exposure enhanced the dermal penetration of zinc oxide nanoparticles and induced inflammatory responses through oxidative stress mediated by MAPKs and NF-κB signaling in SKH-1 hairless mouse skin
UVB暴露促进氧化锌纳米颗粒经皮渗透并由MAPKs和NF-κB信号通路调节氧化应激介导的SKH-1无毛小鼠的皮肤炎症应答
Anu Pal, Shamshad Alam, Lalit K. S. Chauhan, Prem N. Saxena, Mahadeo Kumar, Ghazi N. Ansari, Dhirendra Singh and Kausar M. Ansari
Toxicol. Res., 2016, 5, 1066-1077 DOI: 10.1039/C6TX00026F

5. An in vitro and in vivo bio-interaction responses and biosafety evaluation of novel Au–ZnTe core–shell nanoparticles
新型Au-ZnTe芯壳纳米颗粒体内外生物交互作用应答和生物安全性评价
R. Dunpall and N. Revaprasadu
Toxicol. Res., 2016, 5, 1078-1089 DOI: 10.1039/C6TX00054A

6. A QSPR approach to the ecotoxicity of ionic liquids (Vibrio fischeri) using VolSurf principal properties
QSPR利用VolSurf软件预测（费氏弧菌）离子液体的生态毒性
Alessio Paterno’, Salvatore Scire and Giuseppe Musumarra
Toxicol. Res., 2016, 5, 1090-1096 DOI: 10.1039/C6TX00071A

7. Metallothioneins act downstream of insulin signaling to regulate toxicity of outdoor fine particulate matter (PM2.5) during Spring Festival in Beijing in nematodeCaenorhabditis elegans
金属硫蛋白作用于胰岛素信号通路调节北京春节期间室外细颗粒物（PM2.5）对秀丽隐杆线虫的毒性作用
Ruilong Yang, Qi Rui, Ling Kong, Nan Zhang, Yu Li, Xinyu Wang, Jing Tao, Peiyao Tian, Yan Ma, Jianrong Wei, Guojun Li and Dayong Wang
Toxicol. Res., 2016, 5, 1097-1105 DOI: 10.1039/C6TX00022C

8. Inhaled SiO2 nanoparticles blunt cold-exposure-induced WAT-browning and metabolism activation in white and brown adipose tissue
吸入SiO2纳米颗粒减少寒冷暴露诱导的白色脂肪组织褐变及白色、棕色脂肪组织的代谢活化
Yangsheng Lin, Xi Li, Li Zhang, Yongqiang Zhang, Huili Zhu, Ying Zhang, Zhuge Xi and Danfeng Yang
Toxicol. Res., 2016, 5, 1106-1114 DOI: 10.1039/C6TX00015K

9. The inhibition of cytochrome P450 2A13-catalyzed NNK metabolism by NAT, NAB and nicotine
NAT、NAB和尼古丁抑制细胞色素P450 2A13催化的NNK代谢
Xingyu Liu, Jie Zhang, Chen Zhang, Bicheng Yang, Limeng Wang and Jun Zhou
Toxicol. Res., 2016, 5, 1115-1121 DOI: 10.1039/C6TX00016A

10. Towards a formalin-free hospital. Levels of 15-F2t-isoprostane and malondialdehyde to monitor exposure to formaldehyde in nurses from operating theatres
构建福尔马林free医院：15-F2t异前列腺素和丙二醛水平反映手术室护士的福尔马林暴露情况
Valeria Bellisario, Giulio Mengozzi, Elena Grignani, Massimiliano Bugiani, Anna Sapino, Gianni Bussolati and Roberto Bono
Toxicol. Res., 2016, 5, 1122-1129 DOI: 10.1039/C6TX00068A

11. Proteomic analysis of hippocampus in mice following long-term exposure to low levels of copper
小鼠长期低剂量铜暴露的海马蛋白质组学研究
Qian Sun, Ming Ying, Quan Ma, Zhijun Huang, Liangyu Zou, Jianjun Liu, Zhixiong Zhuang and Xifei Yang
Toxicol. Res., 2016, 5, 1130-1139 DOI: 10.1039/C5TX00456J

12. MicroRNA-21 activation of Akt via PTEN is involved in the epithelial–mesenchymal transition and malignant transformation of human keratinocytes induced by arsenite
PTEN介导MicroRNA-21激活Akt参与砷诱导的人角质细胞上皮间质转化和恶性转化过程
Xiaolin Lu, Yang Liu, Fei Luo, Aihua Zhang, Xinlu Liu, Lu Lu, Le Shi, Jun Li, Junchao Xue, Hui Xu, Weimin Fan and Qizhan Liu
Toxicol. Res., 2016, 5, 1140-1147 DOI: 10.1039/C6TX00041J

13. Protection of baicalin against lipopolysaccharide induced liver and kidney injuries based on 1H NMR metabolomic profiling
1H NMR代谢组学分析黄芩苷对脂多糖诱导肝肾损伤的保护作用
Shanting Liao, Pei Li, Junsong Wang, Qian Zhang, Dingqiao Xu, Minghua Yang and Lingyi Kong
Toxicol. Res., 2016, 5, 1148-1159 DOI: 10.1039/C6TX00082G

14. Effects of multi-component mixtures of polyaromatic hydrocarbons and heavy metal/loid(s) on Nrf2-antioxidant response element (ARE) pathway in ARE reporter-HepG2 cells
多环芳烃和重金属/类金属多组分混合物对抗氧化反应元件（ARE）-HepG2报告基因细胞中Nrf2-ARE通路的作用
Sasikumar Muthusamy, Cheng Peng and Jack C. Ng
Toxicol. Res., 2016, 5, 1160-1171 DOI: 10.1039/C6TX00024J

15. Pro-inflammatory effects of palytoxin: an in vitro study on human keratinocytes and inflammatory cells
水螅毒素的促炎作用：人角质细胞和炎症细胞的体外研究
Marco Pelin, Chiara Florio, Cristina Ponti, Marianna Lucafò, Davide Gibellini, Aurelia Tubaro and Silvio Sosa
Toxicol. Res., 2016, 5, 1172-1181 DOI: 10.1039/C6TX00084C

16. Changes of serum amino acid profiles by an epidermal growth factor receptor mutation and benzo[a]pyrene in mouse lung tumorigenesis
表皮生长因子受体变异和苯丙[a]芘对小鼠肿瘤发生过程中血清氨基酸谱的影响
Pinpin Lin, Yi-Rong Chen, Chao-Yu Chen, Ya-Ting Chang, Jhih-Sheng Chen, Ming-Hsien Tsai, Cheng-Chin Kuo and Hui-Ling Lee
Toxicol. Res., 2016, 5, 1182-1192 DOI: 10.1039/C6TX00010J

17. Specific histone modifications were associated with the PAH-induced DNA damage response in coke oven workers
特定组蛋白修饰与PAH诱导的焦炉工人DNA损伤相关
Zhengbao Zhang, Liping Chen, Xiumei Xing, Daochuan Li, Chen Gao, Zhini He, Jie Li, Xiaonian Zhu, Xinhua Xiao, Shan Wang, Fangping Wang, Zefang Ren, Yongmei Xiao, Shyamali C. Dharmage, Guanghui Dong, Yuxin Zheng and Wen Chen
Toxicol. Res., 2016, 5, 1193-1201 DOI: 10.1039/C6TX00112B

18. Cisplatin nephrotoxicity in male beagle dogs: next-generation protein kidney safety biomarker tissue expression and related changes in urine
顺铂对雄性比格犬的肾毒性： 子代肾脏蛋白安全生物标志物的组织表达及相关尿液改变
J. E. McDuffie, Y. Chen, J. Y. Ma, S. Lee, K. M. Lynch, D. M. Hamlin, L. Nguyen, M. Rizzolio, M. Sonee and S. Snook
Toxicol. Res., 2016, 5, 1202-1215 DOI: 10.1039/C5TX00497G

19. Cytotoxicity and autophagy dysfunction induced by different sizes of silica particles in human bronchial epithelial BEAS-2B cells
不同粒径二氧化硅颗粒诱导人支气管上皮BEAS-2B细胞的细胞毒性和自噬功能紊乱
Qiuling Li, Hejing Hu, Lizhen Jiang, Yang Zou, Junchao Duan and Zhiwei Sun
Toxicol. Res., 2016, 5, 1216-1228 DOI: 10.1039/C6TX00100A

20. Perturbation of epigenetic processes by doxorubicin in the mouse testis
阿霉素引起小鼠睾丸的表观遗传改变
Oluwajoba O. Akinjo, Timothy W. Gant and Emma L. Marczylo
Toxicol. Res., 2016, 5, 1229-1243 DOI: 10.1039/C6TX00078A

21. Counter ions and constituents combination affect DODAX: MO nanocarriers toxicity in vitro and in vivo
反离子及其组分影响DODAX:MO纳米载体的体内外毒性研究
Ana Cristina Norberto Oliveira, Marisa Passos Sárria, Pedro Moreira, Joana Fernandes, Lisandra Castro, Ivo Lopes, Manuela Côrte-Real, Artur Cavaco-Paulo, Maria Elisabete Cunha Dias Real Oliveira and Andreia Castro Gomes
Toxicol. Res., 2016, 5, 1244-1255 DOI: 10.1039/C6TX00074

Correction (更正)
1.Correction: In vitro toxicity evaluation of silica-coated iron oxide nanoparticles in human SHSY5Y neuronal cells
更正：二氧化硅包裹氧化铁纳米颗粒对人SHSY5Y神经元细胞的体外毒性评价
Gözde Kiliç, Carla Costa, Natalia Fernández-Bertólez, Eduardo Pásaro, João Paulo Teixeira, Blanca Laffon and Vanessa Valdiglesias
Toxicol. Res., 2016, 5, 1256-1256 DOI: 10.1039/C6TX90013E