Toxicology Research, 01 November 2016, Issue 5, Page 1493 to 1746
链接：http://pubs.rsc.org/en/Journals/Journal/TX?issueID=TX005006

CONTENTS

Review Article (综述)
1.Developmental windows of susceptibility to inorganic arsenic: a survey of current toxicologic and epidemiologic data
无机砷发育毒性窗口期易感性的毒理学和流行病学数据
P. A. Bommarito and R. C. Fry
Toxicol. Res., 2016, 5, 1503 DOI:10.1039/C6TX00234J

Papers (论著)
1.Adenosine diphosphate involvement in THP-1 maturation triggered by the contact allergen 1-fluoro-2,4-dinitrobenzene
腺苷二磷酸参与接触过敏原1-氟-2，4-二硝基苯诱导的THP-1细胞的成熟
J. D. Martins, A. Silva, I. Ferreira, M. Gonçalo, J. B. A. Custódio, M. C. Lopes, M. R. M. Domingues, B. M. Neves and M. T. Cruz
Toxicol. Res., 2016, 5, 1512 DOI:10.1039/C6TX00240D

2.Role of cytochrome P450s in the male reproductive toxicity of 1-bromopropane
细胞色素酶P450在1-溴丙烷诱导雄性生殖毒性中的作用
Cai Zong, Xiao Zhang, Chinyen Huang, Jie Chang, C. Edwin Garner, Toshihiro Sakurai, Masashi Kato, Sahoko Ichihara and Gaku Ichihara
Toxicol. Res., 2016, 5, 1522 DOI:10.1039/C6TX00164E

3.Accumulation of biosynthesized gold nanoparticles and its impact on various organs of Sprague Dawley rats: a systematic study
生物合成纳米金颗粒的富集及其对SD大鼠多器官作用的系统研究
Adithan Aravinthan, Seralathan Kamala-Kannan, Muthusamy Govarthanan and Jong-Hoon Kim
Toxicol. Res., 2016, 5, 1530 DOI:10.1039/C6TX00202A

4.Microarray analysis and real-time PCR assay developed to find biomarkers for mercury-contaminated soil
运用微阵列分析和实时PCR筛查汞污染土壤的生物标志物
Jing Hou, Xinhui Liu, Baoshan Cui, Junhong Bai and Xiangke Wang
Toxicol. Res., 2016, 5, 1539 DOI:10.1039/C6TX00210B

5.MicroRNA-338-5p modulates pulmonary hypertension-like injuries caused by SO2, NO2 and PM2.5 co-exposure through targeting the HIF-1α/Fhl-1 pathway
MicroRNA-338-5p通过靶向HIF-1α/Fhl-1通路调控SO2, NO2 和PM2.5联合暴露诱导的肺动脉高压样损伤
Xiaotong Ji, Yingying Zhang, Tingting Ku, Yang Yun, Guangke Li and Nan Sang
Toxicol. Res., 2016, 5, 1548 DOI:10.1039/C6TX00257A

6.Effect of quinine-loaded polysorbate-coated nanocapsules on male and female reproductive systems of rats
聚山梨酯包被的奎宁纳米胶囊对雌雄大鼠生殖系统的作用
Aryele Pinto Izaguirry, Natasha Frasson Pavin, Melina Bucco Soares, Cristiano Chiapinotto Spiazzi, Flávio Arci Araújo, Luana Roberta Michels, Fábio Gallas Leivas, Daniela dos Santos Brum, Sandra Elisa Haas and Francielli Weber Santos
Toxicol. Res., 2016, 5, 1561 DOI:10.1039/C6TX00203J

7.Signals involved in the effects of bisphenol A (BPA) on proliferation and motility of Leydig cells: a comparative proteomic analysis
比较蛋白质组学分析介导双酚A（BPA）对睾丸间质细胞增殖和活性效应的信号
Zhuo-Jia Chen, Kun-Shui Zhang, Li-Chen Ge, Hao Liu, Li-Kun Chen, Jun Du and Hong-Sheng Wang
Toxicol. Res., 2016, 5, 1573 DOI:10.1039/C6TX00258G

8.Assessment of synergistic thyroid disrupting effects of a mixture of EDCs in ovariectomized rats using factorial analysis and dose addition
利用因子分析和剂量相加模型评估EDC混合物对卵巢切除大鼠甲状腺干扰作用
Hao Chen, Zhaoping Liu, Xiaopeng Zhang, Xudong Jia, Qian Li, Qing Su and Wei Wang
Toxicol. Res., 2016, 5, 1585 DOI:10.1039/C6TX00193A

9. Global metabolic changes induced by plant-derived pyrrolizidine alkaloids following a human poisoning outbreak and in a mouse model
植物源性吡咯里西啶生物碱介导人群中毒暴发和小鼠模型的整体代谢谱变化
Oliver Robinson, Mireille B. Toledano, Caroline Sands, Olaf Beckonert, Elizabeth J. Want, Rob Goldin, Michael L. Hauser, Alan Fenwick, Mark R. Thursz and Muireann Coen
Toxicol. Res., 2016, 5, 1594 DOI:10.1039/C6TX00221H

10. Resveratrol and pterostilbene attenuated smokeless tobacco induced cardiovascular aberrations in estrogen deficient female rats
白藜芦醇和紫檀芪缓解无烟烟草诱导雌激素缺乏雌性大鼠的心血管异常
A. Nirwane and A. Majumdar
Toxicol. Res., 2016, 5, 1604 DOI:10.1039/C6TX00225K

11. Proteasome inhibitors bortezomib and carfilzomib used for the treatment of multiple myeloma do not inhibit the serine protease HtrA2/Omi
用于治疗多发性骨髓瘤的蛋白酶体抑制剂硼替佐米和卡非佐米无抑制丝氨酸蛋白酶HtrA2/Omi的作用
Vilmos Csizmadia, Paul Hales, Christopher Tsu, Jingya Ma, Jiejin Chen, Pooja Shah, Paul Fleming, Joseph J. Senn, Vivek J. Kadambi, Larry Dick and Francis S. Wolenski
Toxicol. Res., 2016, 5, 1619 DOI:10.1039/C6TX00220J

12. Guarana (Paullinia cupana Mart.) attenuates methylmercury-induced toxicity in Caenorhabditis elegans
瓜拉纳（Paullinia cupana）降低甲基汞对秀丽隐杆线虫的毒性
J Leticia Priscilla Arantes, Tanara Vieira Peres, Pan Chen, Samuel William Caito, Michael Aschner and Félix Alexandre Antunes Soares
Toxicol. Res., 2016, 5, 1629 DOI:10.1039/C6TX00161K

13. Hydroxylated-graphene quantum dots induce cells senescence in both p53-dependent and -independent manner
羟基石墨烯量子点同时以p53依赖或非依赖方式诱导细胞衰老
Xin Tian, Bei-Bei Xiao, Anqing Wu, Lan Yu, Jundong Zhou, Yu Wang, Nan Wang, Hua Guan and Zeng-Fu Shang
Toxicol. Res., 2016, 5, 1639 DOI:10.1039/C6TX00209A

14. Cellular uptake, genotoxicity and cytotoxicity of cobalt ferrite magnetic nanoparticles in human breast cells
人乳腺细胞对钴铁氧体磁性纳米颗粒的吞噬及遗传和细胞毒性
Elif Aşık, Yeliz Akpınar, N. Tülin Güray, Mesude İşcan, Gonca Çakmak Demircigil and Mürvet Volkan
Toxicol. Res., 2016, 5, 1649 DOI:10.1039/C6TX00211K

15. Synthetic cannabinoid, JWH-030, induces QT prolongation through hERG channel inhibition
合成大麻素JWH-030通过抑制hERG通道诱导QT间期延长
Jaesuk Yun, Kyung Sik Yoon, Tac-Hyung Lee, Hyunjin Lee, Sun Mi Gu, Yun Jeong Song, Hye Jin Cha, Kyoung Moon Han, Hyewon Seo, Jisoon Shin, Hye-Kyung Park, Hyung Soo Kim and Young-Hoon Kim
Toxicol. Res., 2016, 5, 1663 DOI:10.1039/C6TX00259E

16. 56Fe irradiation-induced cognitive deficits through oxidative stress in mice
56Fe辐射通过氧化应激导致小鼠认知缺陷
Jiawei Yan, Yang Liu, Qiuyue Zhao, Jie Li, Aihong Mao, Hongyan Li, Cuixia Di and Hong Zhang
Toxicol. Res., 2016, 5, 1672 DOI:10.1039/C6TX00282J

17. Alteration of mitochondrial phospholipid due to the PLA2 activation in rat brains under cadmium toxicity
镉激活PLA2引起大鼠脑部线粒体磷脂改变
Chinnarasu Sivaprakasam, Rajendran Vijayakumar, Mathivanan Arul and Vasanthi Nachiappan
Toxicol. Res., 2016, 5, 1680 DOI:10.1039/C6TX00201C

18. Hepatoprotective activity of viscosine is mediated by attenuation of hepatic macrophages and iNOS expression in CCl4-intoxicated rats
粘性油通过抑制肝巨噬细胞和iNOS表达发挥对CCL4中毒大鼠的肝脏保护作用
Hamid Ali, Nurul Kabir, Muhammad Raza Shah, Akhtar Muhammad, Safdar Ali, Shahab Mehmood, Amjad Ali, Abid Ali and Azra Jahan
Toxicol. Res., 2016, 5, 1688 DOI:10.1039/C6TX00165C

19. Cell mechanotactic and cytotoxic response to zinc oxide nanorods depends on substrate stiffness
氧化锌纳米管对细胞的机械力趋性和细胞毒作用取决于粒子硬度
I. E. Palamà, S. D'Amone, V. Arcadio, M. Biasiucci, A. Mezzi and B. Cortese
Toxicol. Res., 2016, 5, 1699 DOI:10.1039/C6TX00274A

20. Effect of dietary protein or calcium supplement on the expression of collagen I and dentine phosphoprotein of rats with dental fluorosis
饮食摄入蛋白或钙对氟斑牙大鼠I型胶原和牙本质磷蛋白表达的作用
Min Wang, Tianlong Han, Huacheng Chen and Jundong Wang
Toxicol. Res., 2016, 5, 1711 DOI:10.1039/C6TX00288A

21. Metabolomics as a tool to evaluate the toxicity of formulations containing amphotericin B, an antileishmanial drug
运用代谢组学方法对两性霉素B类抗利什曼虫药进行毒性评价
Délia C. M. Santos, Marta L. Lima, Juliano S. Toledo, Paula A. Fernandes, Marta M. G. Aguiar, Ángeles López-Gonzálvez, Lucas A. M. Ferreira, Ana Paula Fernandes and Coral Barbas
Toxicol. Res., 2016, 5, 1720 DOI:10.1039/C6TX00253F

22.Modulation of miRNA-155 alters manganese nanoparticle-induced inflammatory response
调控miRNA-155水平改变纳米锰颗粒诱导的炎性反应
Matthew W. Grogg, Laura K. Braydich-Stolle, Elizabeth I. Maurer-Gardner, Natasha T. Hill, Suraj Sakaram, Madhavi P. Kadakia and Saber M. Hussain
Toxicol. Res., 2016, 5, 1733 DOI:10.1039/C6TX00208K