Toxicology Research,01 January 2017, Issue 6, Page 1 to 106
链接：http://pubs.rsc.org/en/Journals/Journal/TX?issueID=TX006001


CONTENTS

Papers (论著)
1.Synergistic effects of particulate matter (PM2.5) and sulfur dioxide (SO2) on neurodegeneration via the microRNA-mediated regulation of tau phosphorylation
PM2.5和SO₂通过microRNA介导的tau蛋白磷酸化改变协同诱导神经退行性变
Tingting Ku, Minjun Chen, Ben Li, Yang Yun, Guangke Li and Nan Sang
Toxicol. Res., 2017, 6, 7 DOI:10.1039/C6TX00314A

2. Pyrazinamide-induced hepatotoxicity and gender differences in rats as revealed by a ¹H NMR based metabolomics approach
利用¹H NMR代谢组学方法揭示吡嗪酰胺诱导的大鼠肝毒性及性别差异
He Zhao, Zhi-Hong Si, Ming-Hui Li, Lei Jiang, Yong-Hong Fu, Yue-Xiao Xing, Wei Hong, Ling-Yu Ruan, Pu-Ming Li and Jun-Song Wang
Toxicol. Res., 2017, 6, 17 DOI:10.1039/C6TX00245E

3. Lipid droplets alleviate cadmium induced cytotoxicity in Saccharomyces cerevisiae
脂滴减轻镉诱导的酿酒酵母细胞毒性
Selvaraj Rajakumar and Vasanthi Nachiappan
Toxicol. Res., 2017, 6, 30 DOI:10.1039/C6TX00187D

4. Prediction of the effect of formulation on the toxicity of chemicals
不同剂型对化学物毒性的影响预测
Pritesh Mistry, Daniel Neagu, Antonio Sanchez-Ruiz, Paul R. Trundle, Jonathan D. Vessey and John Paul Gosling
Toxicol. Res., 2017, 6, 42 DOI:10.1039/C6TX00303F

5. Effects of sorafenib and cisplatin on preneoplastic foci of altered hepatocytes in fetal turkey liver
索拉非尼和顺铂对火鸡胎肝细胞癌前病灶的作用
Bettina Kaestner, Karsten Spicher, Ulrich Jaehde and Harald Enzmann
Toxicol. Res., 2017, 6, 54 DOI:10.1039/C6TX00342G

6. Tris(2-chloroethyl) phosphate (TCEP) and tris(2-chloropropyl) phosphate (TCPP) induce locomotor deficits and dopaminergic degeneration in Caenorhabditis elegans
磷酸三(2-氯乙基)酯（TCEP）和磷酸三(2-氯丙基)酯（TCPP）诱导秀丽隐杆线虫运动减退及多巴胺能神经元变性
Tiantian Xu, Ping Li, Siyu Wu, Lili Lei and Defu He
Toxicol. Res., 2017, 6, 63 DOI:10.1039/C6TX00306K

7. Modelling compound cytotoxicity using conformal prediction and PubChem HTS data
利用构效和PubChem HTS数据库建模预测化合物细胞毒性
Fredrik Svensson, Ulf Norinder and Andreas Bender
Toxicol. Res., 2017, 6, 73 DOI:10.1039/C6TX00252H

8. Improved hepatic physiology in hepatic cytochrome P450 reductase null (HRN™) mice dosed orally with fenclozic acid
芬克洛酸经口染毒肝细胞色素酶P450还原酶基因敲除小鼠（HRN™）促进肝脏生理改变
James A. Akingbasote, Alison J. Foster, Huw B. Jones, Rhiannon David, Nigel J. Gooderham, Ian D. Wilson and J. Gerry Kenna
Toxicol. Res., 2017, 6, 81 DOI:10.1039/C6TX00376A

9. A DEHP plasticizer alters synaptic proteins via peroxidation
DEHP塑化剂通过过氧化作用改变突触蛋白功能
Shaohui Wang, Pengyan Zhang, Ruifang Liu, Yuan Li, Chao Liu and Xiaomei Liao
Toxicol. Res., 2017, 6, 89 DOI:10.1039/C6TX00361C

10. Application research on PPARα-transgenic mice in preclinical safety evaluation of gemfibrozil
PPARα转基因小鼠在吉非罗齐临床前安全性评价中的应用
Yan Li, Hongmei Mao, Yanfeng Xu, Xiaocen Li, Lishan Pan, Xin Wu, Yang Li, Yi Li and Jun He
Toxicol. Res., 2017, 6, 98 DOI:10.1039/C6TX00271D